Effects of pre-hospital antiplatelet therapy on the incidence of ARDS
W Jin, CC Chuang, H Jin, J Ye, E Kandaswamy… - Respiratory …, 2020 - rc.rcjournal.com
W Jin, CC Chuang, H Jin, J Ye, E Kandaswamy, L Wang, L Zuo
Respiratory Care, 2020•rc.rcjournal.comBACKGROUND: Clinical observations on the potential of pre-hospital antiplatelet therapy in
preventing ARDS have been inconsistent. To further the correlation between antiplatelet
therapy and ARDS, we conducted a meta-analysis to evaluate the effects of pre-hospital
antiplatelet therapy on subjects with ARDS. METHODS: A literature search in major data
banks was performed. We included prospective and retrospective cohorts, case-control
trials, and randomized controlled trials that compared the ARDS incidence in subjects with …
preventing ARDS have been inconsistent. To further the correlation between antiplatelet
therapy and ARDS, we conducted a meta-analysis to evaluate the effects of pre-hospital
antiplatelet therapy on subjects with ARDS. METHODS: A literature search in major data
banks was performed. We included prospective and retrospective cohorts, case-control
trials, and randomized controlled trials that compared the ARDS incidence in subjects with …
BACKGROUND
Clinical observations on the potential of pre-hospital antiplatelet therapy in preventing ARDS have been inconsistent. To further the correlation between antiplatelet therapy and ARDS, we conducted a meta-analysis to evaluate the effects of pre-hospital antiplatelet therapy on subjects with ARDS.
METHODS
A literature search in major data banks was performed. We included prospective and retrospective cohorts, case-control trials, and randomized controlled trials that compared the ARDS incidence in subjects with or without pre-hospital antiplatelet agents.
RESULTS
Meta-analysis of 7 studies (a total of 30,291 subjects) showed significantly lower odds of ARDS in the pre-hospital antiplatelet therapy group compared with subjects with no pre-hospital antiplatelet therapy (odds ratio 0.68, 95% CI 0.56–0.83; P < .001). However, ARDS mortalities in the hospital and ICUs were not affected.
CONCLUSIONS
These findings indicated that pre-hospital antiplatelet therapy was associated with a reduced rate of ARDS but had no effect on the mortality in the subjects at high risk.
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